WHAT DOES LDN-27219 CHEMICAL STRUCTURE MEAN?

Just one specially exciting compound is LDN-27219. Even though most tTG inhibitors are made to bind to the protein crosslinking Energetic web page, LDN-27219 in its place binds on the nucleotide binding pocket in the enzyme while it can be in its closed-point out conformation, and stabilizes that conformation to forestall crosslinking activity.78 S